This commentary delves deeper into the principles behind Students at the Center’s Brainy Approaches to Learning infographic and explains how the brain science behind learning supports the concept of personalized learning. The infographic illustrates research from the report Mind, Brain, and Education that answers the questions: What does brain research tell us about how we learn and how learning, in turn, shapes the architecture of the brain? What is the connection between the stress of poverty and the impact of emotions on learning?